Anti Cyclic Citrullinated PeptideAntibodies (Anti CCP)
An Anti-Cyclic Citrullinated Peptide (Anti-CCP) test is a blood test used to diagnose rheumatoid arthritis (RA). This test measures the levels of antibodies in the blood that target proteins in the body called citrullinated peptides. The test is usually ordered by a rheumatologist or other specialist and involves a simple blood draw. Results are typically available within a few days and are reported as a number or range of numbers indicating the level of anti-CCP antibodies present in the blood. While the Anti-CCP test is a useful tool in the diagnosis of RA, it is not hundred percent accurate and should be interpreted in the context of a patient's symptoms and other diagnostic tests. It is important to note that not all people with RA will have a positive Anti-CCP test, and some people without RA may have a positive test result.
Frequently asked questions
The Anti-CCP test is a more specific test for RA than other tests, such as the rheumatoid factor (RF) test. While RF can be found in the blood of some individuals without RA, anti-CCP antibodies are rarely found in people without RA.
The symptoms of rheumatoid arthritis can vary widely but often include joint pain, swelling, and stiffness, especially in the hands and feet. Other symptoms may include fatigue, fever, and weight loss.
An Anti-CCP test may be ordered by a healthcare provider if they suspect that an individual has RA based on their symptoms, medical history, and other diagnostic tests.
The Anti-CCP test is not typically painful. The healthcare provider may apply a small amount of numbing cream to the area before inserting the needle to make the process more comfortable.