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Histopathology: Small Tissue Biopsy

Histopathology: Small Tissue Biopsy

Includes: 1 Parameters

To confirm the precise medical diagnosis, it is a review of the histopathology test performed elsewhere. To better manage their medical condition, the patient in this test asks a leading pathologist for a second opinion on a previously identified ailment. This test is typically performed in cancer cases that demand an accurate diagnosis and fast and effective therapy.

To confirm the precise medical diagnosis, it is a review of the histopathology test performed elsewhere. To better manage their medical condition, the patient in this test asks a leading pathologist for a second opinion on a previously identified ailment. This test is typically performed in cancer cases that demand an accurate diagnosis and fast and effective therapy.

What Is Histopathology?

Histopathology also called biopsy or pathology report is the study of human tissue under a microscope to detect any indications of disease, injury, or other anomalies. While pathology studies disease, histology studies tissues. Histopathology is thus defined as the study of tissues connected to the disease. The tissue that the pathologist monitor is labelled in a histopathology report. It can recognize the characteristics of cancer's microscopic
appearance. A histopathology report is also known as a biopsy report or a pathology report.

What Can Histopathology: Small Tissue Biopsy Test Diagnose?

Most frequently, histopathology is performed by doctors so that a histopathologist can examine the sample and check for the presence of malignant cells. The following are some of the important issues a histopathologist may report on:

  • Exist any malignant cells here?

  • The tissues seem to be what kind of malignant cells?

  • What proportion of the cells is cancerous? This can be used to gauge how well a treatment is working.

  • It may take some time to view and gather this data. For instance, a surgeon may do a biopsy on numerous lymph nodes and a known malignant region to see if the disease has spread.

A histopathologist will examine the tissue sample and the lymph nodes, understand how many cancerous cells are in each lymph node, and check where those lymph nodes are. A pathologist's study of a biopsy or surgical material, carried out after the specimen has been processed and histological sections have been mounted on glass slides, is known as histopathology. A pathologist examines the tissue sample if a large sample is provided, such
as during surgery, and chooses the portion that is most likely to provide an accurate and useful diagnosis. This portion is then torn apart for inspection, a procedure known as grossing or cutting up. To place larger samples anatomical structures correctly in the cassette, larger samples are chopped. To ensure proper tissue orientation in the cassette, in the block, and finally, on the diagnostic microscopy slide, some specimens (particularly
biopsies) may undergo agar pre-embedding.

Difference Between Biopsy and Histopathology?

Many medical professionals use the terms "biopsy" and "histopathology" interchangeably. A biopsy involves taking a tissue sample and examining it for abnormal cells. Sounds familiar? This is because histopathology entails examining cell samples. In short, a biopsy is a procedure for collecting tissues, whereas histopathology is the study of the sample itself. Furthermore, histopathology may involve examining samples from entire
organs, which is not technically a biopsy. After a biopsy, your doctor may request a biopsy report or a histopathology report.

How Histopathology: Small Tissue Biopsy Test is Done?

Histopathology is the study of disease symptoms through microscopic examination of a biopsy or surgical specimen that has been processed and fixed onto glass slides. The sections are stained with one or more stains to visualize different components of the tissue under a microscope. The test preparations themselves are not necessary. It takes place during surgery. Like in the case of someone whose uterus was removed, the doctors will send the huge organ to determine its true state and the type of care the patient will need. Since the procedure is painful, this requires a lot of work.
This test is performed by experts to detect what the human body is going through. When an organ is removed, it is tested to determine its functioning and condition. A lymph node or a piece of tissue is removed to determine what the human body is going through. Histopathology tests are performed by a specialist, a physician known as a Histopathologist. The specimens obtained during the test are then processed at a specialized histopathology
laboratory using special histological techniques. This procedure may cause some discomfort to the patient.

Histopathology: Small Tissue Biopsy Test Procedure

  • The patient is positioned in such a way that the tumour is easily accessible.

  • Enough clothing will be removed from the patient to make the area more accessible.

  • The technician will administer local anaesthesia to the patient in the region of the tumour.

  • Following anaesthesia, a small incision of around 6mm is made with a scalpel.

  • The Trucut needle of 4mm is slowly inserted through the incision.

  • The sample is slowly collected from the incision and retrieved for the pathologist to examine.

  • The pathologist examines the sample after it has been processed and fixed using a chemical fixer or frozen.

Interpretation Of Histopathology: Small Tissue Biopsy Test Results

A positive histopathology report indicates the presence of abnormal tissues. Typically, this would be a cancer diagnosis. Knowing that a histopathology report shows cancerous cells is understandably upsetting. As a result, a doctor will usually review the report with you and assist you in interpreting the findings. Further testing may be required in some cases to determine the extent of cancerous cells. While your doctor may not have all of the answers
right away, it's critical to understand whether your doctor gives you a specific diagnosis and your next steps in testing or treatment. Many pathologist findings are used to help determine prognosis, particularly in cancer cases.
The prediction or estimate of survival or recovery from disease is known as prognosis. Prognostic indicators may include the following:

  • The disease's size and severity

  • Tumour gradation

  • Cancer spread indicators and extent of spread

Grading system: The types of cancer have different grading systems. The cells are generally scored based on how abnormal they appear under the microscope. Grade 1 tumours appear nearly normal, whereas Grade 4 tumours exhibit more abnormalities. The higher grade indicates the more abnormal the cells are.

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SPECIMEN: Tissue In 10%Formalin

Test Details (Parameters included : 1)

Parameter No. of Parameter


Histopathology: Small Tissue Biopsy

Tissue In 10%Formalin


12:00 PM (Daily)

Tissue in 10% formalin Ambient

Frequently asked questions

Histopathology is the diagnosis and study of tissue diseases using a microscope to
examine tissues and/or cells. Workers in healthcare science receive, dissect, and
prepare tissues for examination and diagnosis to reveal the structure of tissues and

Pathology results are usually available within 2-3 days. Urgent tests may take only a
few minutes to complete, with results available within 24 hours in some cases. Some
pathology tests, on the other hand, can take days or weeks to complete, such as
specialized tests, bacteria cultures, or samples sent overseas.

Histopathologists evaluate biopsies, or samples of tissue or cells, taken from patients
either in the clinic or during surgery. The histopathologist visually inspects tissue
biopsies to check for any obvious anomalies and chooses portions to be examined
more closely under a microscope.

A false negative result incorrectly reports the absence of a condition. These are
usually the result of sampling errors or the biopsy missing the lesion. A second
biopsy will be required if a false negative result is obtained.

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