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Parathyroid Hormone (PTH)

Parathyroid Hormone (PTH)

Routine

Parathyroid Hormone, Intact (iPTH) Test is done to measure your parathyroid hormone levels. Parathyroid hormone is released by your parathyroid glands, four pea-sized glands in neck to control the level of calcium in your bloodstream. PTH hormone regulates serum calcium levels through its effects on bone, kidney and the intestine. In bone, PTH enhances the release of calcium from the large reservoir contained in bones. Bone resorption is the normal destruction of bone by osteoclasts, which are indirectly stimulated by PTH. Binding stimulates osteoblasts to increase their expression of RANKL and inhibits their secretion of osteoprotegerin (OPG). It also controls vitamin D and phosphorus levels. PTH stimulates the conversion of 25-Hydroxy Vitamin D into 1,25-Dihydroxy Vitamin D(by upregulating the activity of 1-alpha-hydroxylase enzyme), which is released into circulation. This form of Vitamin D is the active hormone which stimulates calcium uptake from the intestine. PTH also reduces the reabsorption of phosphate from the proximal tubule of kidney, and enhances the uptake of phosphate from the intestines and bones into the blood. Therefore, the end result is a small net drop in the serum concentration of phosphate. If your body has too low or high parathyroid hormone, you may experience symptoms related to abnormal blood calcium levels. Parathyroid Hormone, Intact (iPTH) Test can help monitor and diagnose disorders of the parathyroid hormone, including hyperparathyroidism and hypoparathyroidism. It can also be helpful in detecting benign or malignant tumours of parathyroid glands.

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Test Details

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Frequently asked questions

If the Parathyroid Hormone, Intact (iPTH) Test shows higher level of PTH, the most common cause (Primary Hyperparathyroidism) is a non-cancerous tumour called Adenoma of one of Parathyroid glands, or less commonly enlargement and hyperplasia of hyperparathyroid glands. Other causes include Kidney disease, which lowers calcium levels and causes body to react by producing extra Parathyroid hormone. Vitamin D deficiency also lowers serum levels of calcium, in turn stimulating production of PTH for calcium homeostasis. Low levels of PTH can be seen after Parathyroid surgery, removal of, or trauma to parathyroid glands due to thyroid / neck surgery.

You should get Parathyroid Hormone, Intact (iPTH) Test to diagnose parathyroid gland disorders. It can also be used to detect malignant or benign tumours of the parathyroid glands. These types of tumours can cause the parathyroid gland to produce too little or too much iPTH leading to hypoparathyroidism or hyperparathyroidism. This test can also be used to detect hypoparathyroidism, a condition in which hypothyroid glands produce too much iPTH leading to high calcium levels in the blood. Parathyroid Hormone, Intact (iPTH) Test can also be used to diagnose hyperparathyroidism.

Parathyroid Hormone, Intact (iPTH) Test is accurate in most cases. But the results can be affected depending on various factors, such as the laboratory where the test has been performed and the equipment used for the test. To ensure the accuracy of the test, you should follow the instructions of your doctor and technician when preparing for the test. You should also inform your doctor if you take biotins and several other medicines that can affect PTH levels and lead to incorrect test results.

PTH hormone regulates serum calcium levels through its effects on bone, kidney and the intestine. In bone, PTH enhances the release of calcium from the large reservoir contained in bones. Bone resorption is the normal destruction of bone by osteoclasts, which are indirectly stimulated by PTH. Binding stimulates osteoblasts to increase their expression of RANKL and inhibits their secretion of osteoprotegerin (OPG). It also controls vitamin D and phosphorus levels. PTH stimulates the conversion of 25-Hydroxy Vitamin D into 1,25-Dihydroxy Vitamin D(by upregulating the activity of 1-alpha-hydroxylase enzyme), which is released into circulation.

High parathyroid hormone (PTH) level is most commonly caused by Primary Hyperparathyroidism, a medical condition that happens when your parathyroid glands release high amount of PTH (due to Parathyroid adenoma or hyperplasia). Other causes of hyperparathyroidism include Kidney failure leading to low 1,25 – dihydroxy Vitamin D levels and hypocalcemia, certain genetic conditions like Multiple Endocrine Neoplasia type 1 and parathyroid cancer, which is very rare.

Parathyroid hormone levels are controlled by a feedback loop of calcium levels to the parathyroid glands in your blood. If you have low calcium levels in your bloodstream, it can stimulate parathyroid hormone release. On the other hand, high calcium levels in your bloodstream can prevent your parathyroid gland from releasing parathyroid hormone. Sometimes due to damage to the parathyroid glands or tumour, too much or little PTH is released, regardless of the feedback loop

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