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HLA B27, PCR

HLA B27, PCR

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Wed, Sat 7.30 PM

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Clinical History

Sample Type
3ml Whole Blood. Transport with cold gel packs at 4- 15ยฐC

Introduction

HLA-B27, also known as Human Leukocyte Antigen B27, is a genetic marker that has been linked to several autoimmune diseases, including ankylosing spondylitis, psoriatic arthritis, and reactive arthritis. Polymerase Chain Reaction (PCR) is a powerful technique used in molecular biology to amplify and analyze DNA sequences. When applied to HLA-B27 testing, PCR enables the identification of this specific genetic marker. This is crucial for diagnosing and monitoring individuals at risk for HLA-B27- related diseases. PCR amplifies the DNA region containing HLA-B27, allowing for accurate detection. Understanding a person's HLA-B27 status through PCR can aid in early disease detection for better patient outcomes.

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Test Details

HLA B27, PCR

Frequently asked questions

HLA B27 PCR testing accurately detects the presence or absence of the HLA B27 gene. However, it's important to note that a positive result doesn't always mean a person will develop the associated diseases, and a negative result doesn't completely rule out the possibility.

Having HLA B27 positivity is closely linked to an increased risk of developing conditions like ankylosing spondylitis, reactive arthritis, and other spondyloarthropathies. It's crucial to understand that not everyone who tests positive for HLA B27 will necessarily develop these conditions.

No, HLA B27 PCR testing alone cannot diagnose specific diseases. It is a supportive test used together with clinical evaluation and other diagnostic tests to aid in the diagnosis of certain autoimmune conditions.

HLA B27 test is not typically included in routine physical exams. It is ordered by a healthcare provider when there is suspicion of autoimmune diseases like ankylosing spondylitis.

HLA B27 PCR testing involves a simple blood draw, which may cause minimal discomfort but is generally not considered painful.

In many cases, you can eat and drink normally before an HLA B27 PCR test. It does not require fasting or any specific dietary restrictions.

HLA B27 PCR test results are typically available within a few days to a week, depending on the laboratory's processing time.

A positive result for the HLA B27 gene indicates that you have this gene in your DNA, which is linked to a higher risk of developing certain autoimmune diseases. However, it does not alone confirm a diagnosis.

Having a negative HLA B27 test doesn't necessarily rule out the possibility of ankylosing spondylitis. The diagnosis depends on various factors, including clinical symptoms and other diagnostic tests.

HLA B27 testing is not commonly used as a general genetic screening tool. It is specific to certain autoimmune conditions rather than being a broad test for genetic screening.

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